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Pharmacology
Pharmacology

Pharmacology

Pharmacology

The Pharmacology department brings together 6 sectors of activity: the regional pharmacovigilance center ( CRPV ) , the pharmacoepidemiology and health data analysis , the Addictovigilance – Center for evaluation and information on drug dependence ( CEIP -A ) , the biological units of clinical pharmacology and toxicology and forensic toxicology, the clinical pharmacology unit.

The Pharmacology department brings together 6 sectors of activity: the regional pharmacovigilance center ( CRPV ) , the pharmacoepidemiology and health data analysis , the Addictovigilance – Center for evaluation and information on drug dependence ( CEIP -A ) , the biological units of clinical pharmacology and toxicology and forensic toxicology, the clinical pharmacology unit.

  • Consulting & team

    Cardiac adverse effects associated with anti-cancer drugs (cardio-onco-pharmacology)

    Professor Joachim Alexandre, Dr Charles Dolladille, Dr Damien Legallois, Dr Anne Flore Plane, Dr Angélique Da Silva
    Make an appointment
    Consultation schedule
    not specified

      Composition of service

      Team detail
      Veronique Lelong Boulouard

      Pr Véronique Lelong Boulouard

      head of service
      Melanie Nonnemacher

      Melanie Nonnenmacher

      senior health executive

    • Our support

      Tasks

      These 6 sectors have distinct missions but common objectives which are as follows:

      • evaluation and monitoring of the effectiveness and safety of medications and psychoactive substances (benefit/risk balance of drug prescription)
      • information on medication and psychoactive substances
      • research and development around medicines and psychoactive substances
      • teaching medical pharmacology and the proper use of medicine and psychoactive substances
      Caen Normandy Regional Pharmacovigilance Center
      • Collection and analysis of adverse reaction reports (MA, misuse, medication errors, occupational exposure, abuse – excluding psychoactive substances, etc.).
        • Transmission of cases to national ( ANSM ) and European (EMA) authorities.
        • Management of drug iatrogenic alerts
        • New effects, serious effects, drug interactions, abnormally high frequency of occurrence...
      • Responses to inquiries 
        • Information on the risks associated with drugs and their proper use
        • Overdose, pregnancy, child, elderly, drug combinations...
      • Information and training of health professionals
      • Expertise, advice and investigation with ANSM and ARS
      • Contribution to scientific progress → publications

      Declaration via the Ministry of Health portal Ministry portal
      Contact: 02 31 06 46 72

      Pharmacovigilance bulletins below:

      E-mail
      Pharmaco-epidemiology and health data analysis unit

      Sector specialized in:

        • Identification and characterization of adverse drug reactions in the population
        • Structuring and analysis of massive health data
      • Collaboration with many disciplines (sustained scientific publication activity)
        • Recent posts below
      • Development of new health data analysis tools
      • Participation in several CHU activities related to the development of artificial intelligence:
        • AI steering committee – health data warehouse at Caen University Hospital
        • Proof of concept project on cancer immunotherapy in connection with the health data warehouse
        • Integrative Artificial Intelligence development on project
        • Methodological COTECH of Caen Normandy University Hospital
      Addictovigilance – Center for Assessment and Information on Pharmacodependence Bretagne-Normandie ( CEIP-A )

      Evaluation of the drug dependence potential of psychoactive substances, medicated or not

      • Collection, analysis, documentation of clinical cases of drug dependence: abuse, misuse, withdrawal syndromes and health complications
      • Collection and analysis of falsified prescriptions as well as various other signals in the field of drug addiction and substance dependence
      • Responses to inquiries 
      • Information and training of health professionals on drug dependence and the abuse of psychoactive substances in the inter-region
      • Expertise, advice and investigation with ANSM and ARS
      • Contribution to scientific progress → publications

      Contact : 02 31 06 44 60

      E-mail
      Biological Unit of Pharmacology and Clinical Toxicology

      Research and dosage of drugs and narcotics:

      • Pharmacological Therapeutic Monitoring
        • Dosage Adjustment (Toxicity/Efficacy)
        • Compliance monitoring
        • Pharmacogenetics (personalized therapy and dosage adjustment)
      • Clinical toxicology
        • Research, identification, quantification of drugs and narcotics involved in drug poisoning (accidental or voluntary administration)
      • Clinical research protocol
        • Dosage of drugs in the context of clinical research activities
      directories of laboratory analyzes of the CHU de Caen Normandie
      Biological Unit of Forensic Toxicology
      • Forensic toxicology · E-mail
        • Dosage of narcotics and road alcohol on blood and saliva
        • Investigation of cause of death
      Clinical Pharmacology Unit
      Picaro die

      PICARO care line: prevention and management of adverse cardiac effects associated with drugs prescribed in oncology:

      • Specialized cardio-onco-pharmacology consultations
      • CPR PICARO
      • PICARO regional care pathway project
      • Mainly intended for medical oncologists or organ specialists competent in oncology

      Contact: 02 31 06 46 70   Email

      Clinical research activity :

      • in progress: 2 PHRC -N, 1 PHRC -I, 1 APRI 1
      • Bioserenity-CHU Caen collaboration
      • Attachment to the Clinical Research Center (Pr Alexandre: deputy coordinator)

      Useful document(s)

      Vigina

      Vigina

      April 2025
      Reporting poster

      Reporting poster

      Declare an adverse effect or addiction
      AddictoVigilance Center

      AddictoVigilance Center

      How and what to report to your AddictoVigilance center

      • Platforms

      • Research & teaching

        Attachments to research teams

        The members of the Pharmacology Department are currently attached to 2 research teams of the UFR Santé of the University of Caen-Normandy:

        • INSERM U1086 ANTICIPE team (Dir. Pr G Launoy)
        • INSERM U1075 COMÈTE team (Dir. Pr T Freret)

        Main themes

        The main themes of the Department's teacher-researchers are linked to 2 of the HCERES axes of the CHU, namely the Cancerology axis and the Heart-Brain axis.

        Topic “drugs and cancers”:

        • Cardio-oncology (J. Alexandre)
        • Immuno-oncology (C. Dolladille)

        Theme "Medicines, cognition and aging, consequences on mobility" (V. Lelong-Boulouard) with the development of a theme "Elderly subjects (mobility, cognition) and anti-cancer"

        Scientific activities

        All members of the Pharmacology Department participate in scientific publication activities by promoting the activities, tools and know-how of the department: analysis of health databases and research in pharmacoepidemiology, and translational approach ranging from pharmacology experimental to clinical pharmacology.

        Funded projects

        • PHRC ALDOCURE (J Alexandre) 850 k€ (85 inclusions at Caen University Hospital, 210 throughout France)
        • PHRC national SPONSOR (J Alexandre) 1000 k€
        • Inter-regional PHRC
        • IRAF financing Biotronik 160 k€
        • APRI, other tenders…

        Education

        Academic teaching : approximately 210 hours of lessons

        • UFR Health (minor health, Medicine, Pharmacy)
        • School of maieutics
        • Others ( IDE , IADE , IBODE , UFR Pharmacy, IBFA, etc.)
        • Training of interns in specialized medicine, general medicine, biology, hospital pharmacy (DES and FST in medical and therapeutic pharmacology) and externs in pharmacy and medicine

        A pharmacovigilance study in VigiBase®

        Haematologic malignancies associated with clozapine v. all other antipsychotic agents: a pharmacovigilance study in VigiBase®

        JAMA Oncol 2020

        Immune checkpoint inhibitor rechallenge after immune-related adverse events in patients Witt cancer

        Lancet Hematology 2021

        Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomized controlled trials and a retrospective study of the WHO pharmacovigilance database

        • The latest news related to the service…

        Medical biology laboratory

        Medical biology laboratory

        The directory of medical biology analyzes of the CHU Caen Normandie is available here.
        Sampling manual

        Locate / contact service

        Pharmacology

        Building Biology Research

        Avenue de la Côte de Nacre
        CS 30001
        14033 Caen cedex 9

        Pharmacology

        Service Secretariat

        02 31 06 46 70
        e-mail
        Level GPS accessHall E-mail
        Pharmacology
        Building Biology Research
        Level : 0
        GPS Access: BBR Logistics
        Biology Research Building
        : 02 31 06 46 70