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Immunology · HLA
Immunology · HLA

Immunology · HLA

Immunology · HLA

The laboratory provides diagnostictesting for patients with immune system disorders or conditions affecting the immune response. These include autoimmune diseases, immunodeficiencies, monoclonal gammopathies, allergic diseases, and monitoring of biotherapies. It is a reference laboratory for the investigation of anaphylactic reactions and hereditary immunodeficiencies.

The Histocompatibility ( HLA ) sector manages the care of donors and recipients for organ and hematopoietic stem cell transplants, typing HLA within the framework of HLA -disease associations , as well as the registry of voluntary bone marrow donors ( DVMO ).

The laboratory provides diagnostictesting for patients with immune system disorders or conditions affecting the immune response. These include autoimmune diseases, immunodeficiencies, monoclonal gammopathies, allergic diseases, and monitoring of biotherapies. It is a reference laboratory for the investigation of anaphylactic reactions and hereditary immunodeficiencies.

The Histocompatibility ( HLA ) sector manages the care of donors and recipients for organ and hematopoietic stem cell transplants, typing HLA within the framework of HLA -disease associations , as well as the registry of voluntary bone marrow donors ( DVMO ).

Team

Service composition

Immunology

  • 1 University Professor · Hospital Practitioner
  • 2 Hospital Practitioners
  • 1 Specialist Assistant
  • 1 University Hospital Assistant
  • 1 Secretary
  • 7 Laboratory Technicians

Histocompatibility (HLA)

  • 1 University Professor · Hospital Practitioner
  • 1 Hospital Practitioner
  • 1 Specialist Assistant
  • 1 Secretary
  • 1 Engineer
  • 6 Laboratory Technicians
Team details
Professor Olivier Toutirais

Professor Olivier Toutirais

Head of department

Manuela Leroux

Senior healthcare executive

Our services

Activities

The immunology department performs assessments within the framework
  • autoimmunity autoantibodies linked to connective tissue diseases, polyarthritis myositis, vasculitis, antiphospholipids, endocrinopathies (thyroid, diabetes) digestive and hepatopathies, dysthyroidism, onconeurals, autoimmune skin diseases.
  • Dysglobulinemias: electrophoresis and immunofixation of immunoglobulins (in blood and urine), assays of immunoglobulins and light chains
  • Acquired or hereditary immunodeficiencies: standard and extended lymphocyte phenotyping, immunoglobulin class and subclass assays, vaccine responses
  • exploration of the complement : functional CH50 and weight-related
  • Allergy testing: specific IgE assays, investigation of anaphylactic reactions, basophil activation tests, multi-allergen microchips
  • Flow cytometry of bronchoalveolar lavage fluid and search for paroxysmal nocturnal hemoglobinuria clone
  • Immunomonitoring of biotherapies using monoclonal antibodies, antibody assays and immunization screening, and CAR-T cell therapy
The HLA sector achieves
  • 24/7 emergency HLA and HLA donor-recipient genotyping for organ and hematopoietic stem cell transplantation : genotyping lymphocyte crossmatching prior to organ transplantation
  • the search and identification of anti-HLA
  • HLA typing and diseases.
  • quantification of CD34-positive cells
  • Monitoring donor/recipient chimerism after allogeneic hematopoietic stem cell transplantation.

Platforms

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Medical biology laboratory

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Locate / contact the service

Immunology · HLA

Biology Building · Research

Avenue de la Côte de Nacre CS 30001 14033 Caen cedex 9

Immunology · HLA

Secretariat of the department

02 31 27 25 51
e-mail
LevelGPS accessParkingEntrance
Immunology Laboratory
Biology Building · Research
Level : 1
GPS access: BBR · Public
Parking: Parking 2
Access to the Biology Research Building
: 02 31 27 25 51
HLA Laboratory
Biology Building · Research
Level : 1
GPS access: BBR · Public
Parking: Parking 2
Access to the Biology Research Building
: 02 31 06 59 49