OTO-RHINO-LARYNGOLOGIE (ORL) ET CHIRURGIE CERVICO-FACIALE

L'activité de recherche

Le service d'ORL travaille à l'élaboration de nouveaux protocoles de traitement et de nouvelles techniques chirurgicales. Il participe ainsi à plusieurs études visant à améliorer le diagnostic et la prise en charge et la qualité de vie en cancérologie ORL, dans les pathologies ORL fréquentes (phlegmon de l'amygdale...) ou plus rares (maladie de Rendue Osler...)

Il intervient également dans la recherche clinique et fondamentale en liens avec les équipes INSERM U1086 ANTICIPE « CANCERS ET PREVENTIONS » et U 1075 "COMETE" qui travaille sur l'oreille interne et son retentissement sur le cerveau.

Publications

• Anatomy and surgical approach of rat’s vestibular sensors and nerves.
  Hitier M, Sato G, Zhang YF, Zheng Y, Besnard S, Smith PF, Curthoys IS.
  J Neurosci Methods. 2016 May 19.
• What are the real waiting times for therapeutic management of head and neck cancer: a study in the general population in the north-west of France.
  Guizard AV, Dejardin O, Launay L, Bara S, Lapôtre-Ledoux B, Babin E, Launoy G, Ligier K.
  Eur Arch Otorhinolaryngol. 2016 Apr 27.
• What vestibular tests to choose in symptomatic patients after a cochlear implant? A systematic review and meta-analysis.
  Abouzayd M, Smith PF, Moreau S, Hitier M.
  Eur Arch Otorhinolaryngol. 2016 Apr 8.
• Neurological involvement in hereditary hemorrhagic telangiectasia.
  Labeyrie PE, Courthéoux P, Babin E, Bergot E, Touzé E, Pelage JP.
  J Neuroradiol. 2016 Apr 5.
• Corrigendum: Human rather than ape-like orbital morphology allows much greater lateral visual field expansion with eye abduction.
  Denion E, Hitier M, Levieil E, Mouriaux F.
  Sci Rep. 2016 Jan 20.
• State of the art of endoscopic frontal sinus cerebrospinal fluid leak repair.
  Patron V, Roger V, Moreau S, Babin E, Hitier M.
  Eur Ann Otorhinolaryngol Head Neck Dis. 2015
• Human rather than ape-like orbital morphology allows much greater lateral visual field expansion with eye abduction.
  Denion E, Hitier M, Levieil E, Mouriaux F.
  Sci Rep. 2015 Jul 20
• Lateral Semicircular Canal Asymmetry in Idiopathic Scoliosis: An Early Link between Biomechanical, Hormonal and Neurosensory Theories.
  Hitier M, Hamon M, Denise P, Lacoudre J, Thenint MA, Mallet JF, Moreau S, Quarck G.
  PLoS One. 2015 Jul 17
• Unique human orbital morphology compared with that of apes
  Denion E, Hitier M, Guyader V, Dugué AE, Mouriaux F.
  Sci Rep. 2015 Jun 25
• Spontaneous Cyst of the Cervical Sergment of the Thoracic Duct: Literature Review.
  Roger V; Babin E; Hitier M; Capovilla M; Blanchard D; Ann Otolaryngol
  Rhinol 2015 (2)4
• The forgotten foramina: a study of the anterior cribriform plate.
  Patron V, Berkaoui J, Jankowski R, Lechapt-Zalcman E, Moreau S, Hitier M.
  Surg Radiol Anat. 2015 Sep;37(7)
• Facial reanimation by muscle-nerve neurotization after facial nerve sacrifice.
  Taupin A, Labbé D, Babin E, Fromager G.Case
  report. Ann Chir Plast Esthet. 2015 Sep 21.
• French Society of ENT (SFORL) guidelines for care pathway organization in head and neck oncology (short version). Early management of head and neck cancer.
  Cuny F, Babin E, Lacau-Saint-Guily J, Baujat B, Bensadoun R, Bozec A, Chevalier D, Choussy O, Deneuve S, Fakhry N, Guigay J, Makeieff M, Merol JC, Mouawad F, Pavillet J, Rebiere C, Righini C, Sostras MC, Tournaille M, Vergez S; SFORL work group.
  Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Sep;132(4):205-8.
• Guidelines (short version) of the French Otorhinolaryngology – Head and Neck Surgery Society (SFORL) on patient pathway organization in ENT: The therapeutic decision-making process.
  Deneuve S, Babin E, Lacau-St-Guily J, Baujat B, Bensadoun RJ, Bozec A, Chevalier D, Choussy O, Cuny F, Fakhry N, Guigay J, Makeieff M, Merol JC, Mouawad F, Pavillet J, Rebiere C, Righini CA, Sostras MC, Tournaille M, Vergez S.
  Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Sep
• Laryngeal preservation in ENT oncology. Retrospective series of 246 patients managed in the Caen University Hospital and François Baclesse Cancer Care Center between 1998 and 2008.
  Cuny F, Meunier A, Heutte N, Rame JP, De Raucourt D, Babin E, Blanchard D.
  Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Jun
• The labour market, psychosocial outcomes and health conditions in cancer survivors: protocol for a nationwide longitudinal survey 2 and 5 years after cancer diagnosis (the VICAN survey).
  Bouhnik AD, Bendiane MK, Cortaredona S, Sagaon Teyssier L, Rey D, Berenger C, Seror V, Peretti-Watel P; members of VICAN Group.
  BMJ Open. 2015 Mar 24
• Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas.
  Veracini L, Grall D, Schaub S, Beghelli-de la Forest Divonne S, Etienne-Grimaldi MC, Milano G, Bozec A, Babin E, Sudaka A, Thariat J, Van Obberghen-Schilling E.
  Oncotarget. 2015 Apr 10
• Management of surgical margins after endoscopic laser surgery for early glottic cancers: a multicentric evaluation in French-speaking European countries.
  Fakhry N, Vergez S, Babin E, Baumstarck K, Santini L, Dessi P, Giovanni A.
  Eur Arch Otorhinolaryngol. 2015 Jun
• Prognostic value of microscopic lymph node involvement in patients with papillary thyroid cancer.
  Bardet S, Ciappuccini R, Quak E, Rame JP, Blanchard D, de Raucourt D, Babin E, Michels JJ, Vaur D, Heutte N. J Clin
  Endocrinol Metab. 2015 Jan
• Multicentric evaluation of strategies for treatment of T1a glottic carcinomas.
  Vergez S, Baumstarck K, Lagier A, Santini L, Dessi P, Babin E, Giovanni A; Fakhry N.
  Eur Arch Otorhinolaryngol. 2015 Jan
• Quality of life tools in head and neck oncology. Heutte N, Plisson L, Lange M, Prevost V, Babin E. Eur AnnOtorhinolaryngol Head Neck Dis.
• Cooperation between Medicine and Sociology in Head and Neck Oncology. Babin E., Grandazzi G. Otolaryngol Head Neck Surg.
• Assessment of nutritional status and quality of life in patients treated for head and neck cancer. Prevot V, Joubert C, Heutte N, Babin E. Eur AnnOtorhinolaryngol Head Neck Dis.
• Vestibular function and cochlear implant. Robard L, Hitier M, Lebas C, Moreau S. Eur Arch Otorhinolaryngol.
• Jugular bulb abnormalities in patients wuth Menière's disease using high-resolution computed tomogaphy.Hitier M, Sato G, Moreau S, Patron V. Eur Arch Otorhinolaryngol.

Publications 2003-2013

• New endovascular treatment of vertigo caused by jugular bulb abnormalities. Hitier M, Barbier C, Thénint M-a, Moreau S, Courthéoux P, Patron V. Surgical Innovation. (In press)
• Paragangliome laryngé imitant un hémangiome laryngé. Plisson L, Patron V, Luna Azoulay B, Babin E, Hitier M. Rev Laryngol Otol Rhinol (Bord). (In press)
• Persistent stapedial arteries in human: from phylogeny to surgical consequences. Hitier M, Zhang M, Labrousse M, Barbier C, Patron V, Moreau S. Surg Radiol. Anat. 2013
• Exclusive radiotherapy for stage T1-T2N0M0 laryngeal cancer: Retrospective study of 59 patients at CFB and CHU de Caen. Cuny F, Géry B, Florescu C, Clarisse B, Blanchard D, Rame JP, Babin E, De Raucourt D. Eur AnnOtorhinolaryngol Head Neck Dis. 2013
• Aspergillus vertebral osteomyelitis in immunocompetent subjects : case report and review of the literature. Nicolle A, de la Blanchardière A, Bonhomme J, Hamon M, Leclercq R, Hitier M. Infection. 2013
• "Le Jeu de la Nature". Patron V, Thénint MA, Robard L, Boittin F, Babin E, Hitier M. Eur Ann Otorhinolaryngol Head Neck Dis. 2013
• Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. Lefebvre JL, Pointreau Y, Rolland F, Alfonsi M, Baudoux A, Sire C, de Raucourt , D, Malard O, Degardin M, Tuchais C, Blot E, Rives M, Reyt E, Tourani JM, Geoffrois L, Peyrade F, Guichard F, Chevalier D, Babin E, Lang P, Janot F, Calais G, Garaud P, Bardet E. J Clin Oncol. 2013
• Predictive factors for lateral occult lymph node metastasis in papillary thyroid carcinoma. Patron V, Hitier M, Bedfert C, Métreau A, Dugué A, Jegoux F. Eur Arch Otorhinolaryngol. 2013
• Dual-phase 99mTc sestamibi scintigraphy with neck and thorax SPECT/CT in primary hyperparathyroidism: a single-institution experience. Ciappuccini R, Morera J, Pascal P, Rame JP, Heutte N, Aide N, Babin E, Reznik Y, Bardet S. Clin Nucl Med. 2012
• Occult lymph node metastases increase locoregional recurrence in differentiated thyroid carcinoma. Patron V, Hitier M, Bedfert C, Le Clech G, Jégoux F. Ann Otol Rhinol Laryngol. 2012
• Evaluation of the chemical model of vestibular lesions induced by arsanilate in rats. Vignaux G, Chabbert C, Gaboyard-Niay S, Travo C, Machado ML, Denise P, Comoz F, Hitier M, Landemore G, Philoxène B, Besnard S. Toxicol Appl Pharmacol. 2012
• Les cellulites orbitaires. Mouriaux F, Rysanek B, Babin E, Cattoir V. J Fr Ophtalmol. 2012
• Isolated hypoglossal palsy due to cervical osteophyte. Patron V, Roudaut PY, Lerat J, Vivent M, Bessède JP, Aubry K. Eur Ann Otorhinolaryngol Head Neck Dis. 2012
• Right fourth branchial cyst presenting as retropharyngeal collection in a neonate. Patron V, Roudaut PY, Brosset P, Vivent M, Aubry K, Leboulanger N. J Perinatol. 2012
• Psychosocial quality of life in hereditary haemorrhagic telangiectasia patients. Loaëc M, Morinière S, Hitier M, Ferrant O, Plauchu H, Babin E. Rhinology. 2011
• Peripheral facial paralysis and bilateral carotid pseudoaneurysms of petrous localization : a case report. Lerat J, Orsel S, Mounayer C, Riva R, Roudaut PY, Patron V, Bessede JP, Aubry K. Skull Base Rep. 2011
• Stroke in hereditary hemorrhagic telangiectasia patients. New evidence for repeated screening and early treatment of pulmonary vascular malformations: two case reports. Ribeiro E, Cogez J, Babin E, Viader F, Defer G. BMC Neurol. 2011
• Management of total laryngectomy patients over time: from the consultation announcing the diagnosis to long term follow-up. Babin E, Blanchard D, Hitier M. Eur Arch Otorhinolaryngol. 2011
• Corps étranger oesophagien: prothèse dentaire. Robard L, Blanchard D, Babin E, Loaec M, Hitier M. Rev Laryngol Otol Rhinol (Bord). 2011
• Pattern of lateral neck metastases in N0 papillary thyroid carcinoma. Patron V, Bedfert C, Le Clech G, Aubry K, Jegoux F. BMC Cancer. 2011
• Cancers thyroïdiens différenciés de l'enfant. L'expérience normande. Blanchard D, Choussy O, Rame J, Bequigon A, Dehesdin D, De Raucourt D, Bardet S, Babin E. Rev Laryngol Otol Rhinol (Bord). 2011
• The ventrolateral surgical approach to labyrinthectomy in rats: anatomical description and clinical consequences. Hitier M, Besnard S, Vignaux G, Denise P, Moreau S. Surg Radiol Anat. 2010
• Radiology quiz case 2. Gradenigo syndrome caused by right petrous apicitis. Hitier M, Boutet C, Faure C, Abadie C, Moreau S. Arch Otolaryngol Head Neck Surg. 2010
• Transethmoidal drainage of frontal brain abscesses. Patron V, Orsel S, Caire F, Aubry K, Jégoux F. Surg Innov. 2010
• Endonasal trans-ethmoidal drainage of a cerebral abscess. Patron V, Orsel S, Caire F, Turlure P, Bessède JP, Aubry K. Skull Base. 2010
• Nasolacrimal duct oncocytoma: an unusual cause of chronic epiphora. Delas B, Bertrand M, Babin E, François A, Marie JP, Dehesdin D, Choussy O. Ear Nose Throat J. 2010
• Fasciite crâniale. Blanchard D, Hibon R, Hitier M, Galateau-Sallé F, Abadie-Koebele C, Babin E. Rev Laryngol Otol Rhinol (Bord).2010
• Role of radiotherapy in the treatment of nasoethmoidal adenocarcinoma. Choussy O, Ferron C, Védrine PO, Toussaint B, Liétin B, Marandas P, Babin E, De Raucourt D, Reyt E, Cosmidis A, Makeieff M, Dehesdin D. Arch Otolaryngol Head Neck Surg. 2010
• Endoscopic treatment of pharyngo-esophageal diverticulum in child. Patron V, Godey B, Aubry K, Jegoux F. Int J Pediatr Otorhinolaryngol. 2010
• Hémangiopérycitome naso-sinusien: à propos de 4 cas. Luna BA, Chraibi M, Abd IA, Coste A, Babin E. Rev Laryngol Otol Rhinol (Bord). 2010
• Sympathetic B antagonist prevents bone mineral density decrease induced by labyrinthectomy. Denise P, Besnard S, Vignaux G, Sabatier JP, Edy E, Hitier M, Levasseur R. Aviakosm Ekolog Med. 2009
• Vagal paraganglioma of the neck: a case report. Choussy O, Babin E, De Barros A, Bon-Mardion N, Marie JP, Dehesdin D. Ear Nose Throat J. 2009
• Intérêt de l'immuninutrition péri-opéatoire en Carcinologie Cervico-Faciale. Mayaleh HA, Vayer C, Amsellem C, Bouvet A, Duval N, Poiree B, Tran M, Lepeltier V, Hitier M, Rame JP, Louis Y, De Raucourt D Rev Laryngol Otol Rhinol (Bord). 2009
• Head and neck cancer in young people: a series of 52 SCCs of the oral tongue in patients aged 35 years or less. Mallet Y, Avalos N, Le Ridant AM, Gangloff P, Moriniere S, Rame JP, Poissonnet G, Makeieff M, Cosmidis A, Babin E, Barry B, Fournier C. Acta Otolaryngol. 2009
• Silent sinus syndrome with spontaneous orbital floor reconstruction. Babin E, Bertrand M, Retout A, Gardea E, Choussy O. B-ENT. 2009
• Qualité de vie psychosociale chez les patients ayant une laryngectomie totale. Babin E, Beynier D, Le Gall D, Hitier M. Rev Laryngol Otol Rhinol (Bord).2009
• Résultats préliminaires des trachéotomies percutanées. Luna Azoulay B, Béquignon A, Babin E, Moreau S. Ann Otolaryngol Chir Cervicofac. 2009
• Personal and social identity transformations that occur over time among patients with total laryngectomy. Babin E, Edy E, Béquignon A, Hitier M. J Otolaryngol Head Neck Surg. 2008
• Need for neck dissection after radiochemotherapy? A study of the French GETTEC Group. Vedrine PO, Thariat J, Hitier M, Janot F, Kaminsky MC, Makeieff M, DeRaucourt D, Lapeyre M, Toussaint B; French Groupe d'Etude des Tumeurs de la Tête et du Cou Group. Laryngoscope. 2008
• Chirurgie endonasale sous guidage endoscopique assisté par ordinateur dans l'accès transsphénoïdal des lésions de l'hypophyse. Hitier M, Hibon R, Candelier G, Guarnieri J, Moreau S, Babin E. Rev Laryngol Otol Rhinol (Bord). 2009
• Macroscopic lymph-node involvement and neck dissection predict lymph-node recurrence in papillary thyroid carcinoma. Bardet S, Malville E, Rame JP, Babin E, Samama G, De Raucourt D, Michels JJ, Reznik Y, Henry-Amar M. Eur J Endocrinol.2008
• PET/CT for assessing mandibular invasion by intraoral squamous cell carcinomas. Babin E, Desmonts C, Hamon M, Bénateau H, Hitier M. Clin Otolaryngol. 2008
• Quality of life in head and neck cancers patients: predictive factors, functional and psychosocial outcome. Babin E, Sigston E, Hitier M, Dehesdin D, Marie JP, Choussy O Eur Arch Otorhinolaryngol. 2008
• Adenocarcinoma of Ethmoid: a GETTEC retrospective multicenter study of 418 cases. Choussy O, Ferron C, Védrine PO, Toussaint B, Liétin B, Marandas P, Babin E, De Raucourt D, Reyt E, Cosmidis A, Makeiff M, Dehesdin D; GETTEC Study Group. Laryngoscope. 2008
• Squamous cell carcinoma of the nasal columella: a retrospective study of 66 cases from the GETTEC. Choussy O, Babin E, Temam S, Cosmidis A, Vedrine PO, De Raucourt D, Sarini J, Bessede JP, Lienhardt PY, Dehesdin D; GETTEC study group. Eur Arch Otorhinolaryngol. 2008
• [Otologic sequels in velopalatine clefts. Analysis and management]. Paquot-Le Brun C, Babin E, Moreau S, Bequignon A. Rev Stomatol Chir Maxillofac. 2007
• Ischémie aiguë mésentérique et cancer du cavum. Pigneret S, Baudon Lecame M, Chédru Legros V, Choussy O, Babin E. Rev Laryngol Otol Rhinol (Bord). 2007
• Unusual presentation of oropharyngeal Kaposi's sarcoma. Choussy O, Van Haverbeke C, Babin E, Francois A, Duval-Modeste AB, Dehesdin D. Head Neck. 2008
• [Primary malignant tumors of the lacrimal sac and nasolacrimal duct]. Choussy O, Babin E, Delas B, Bailhache A, François A, Marie JP, Dehesdin D. Ann Otolaryngol Chir Cervicofac. 2007
• Pathology quiz case 3. Kikuchi-Fujimoto disease. Choussy O, Babin E, Le Pessot F, Bonmardion N, Marie JP, Dehesdin D. Arch Otolaryngol Head Neck Surg. 2007
• Inflammatory myofibroblastic tumour of the left mandibular angle. Rouleau V, Tahery J, Rod J, Louis Y, Galateau-Sallé F, Babin E. J Otolaryngol. 2006
• Distribution of ENG and ACVRL1 (ALK1) mutations in French HHT patients. Lesca G, Burnichon N, Raux G, Tosi M, Pinson S, Marion MJ, Babin E, Gilbert-Dussardier B, Rivière S, Goizet C, Faivre L, Plauchu H, Frébourg T, Calender A, Giraud S; French Rendu-Osler Network. Hum Mutat. 2006
• Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses. Babin E, Rouleau V, Vedrine PO, Toussaint B, de Raucourt D, Malard O, Cosmidis A, Makaeieff M, Dehesdin D. J Laryngol Otol. 2006
• Early-stage glottic cancer: oncological results and margins in laser cordectomy. Sigston E, de Mones E, Babin E, Hans S, Hartl DM, Clement P, Brasnu DF. Arch Otolaryngol Head Neck Surg. 2006
• [Detection of the sentinal node in squamous-cell carcinoma of the oral cavity and oropharynx. Preliminary study]. Bénateau H, Babin E, Soubeyrand E, Nicolas J, Blaizot X, Comoz F, Béquignon A, Bouvard G, Compère JF, Chesnay E. Rev Stomatol Chir Maxillofac. 2005
• [Oncology and quality of life. Study in head and neck cancer]. Babin E, Joly F, Vadillo M, Dehesdin D. Ann Otolaryngol Chir Cervicofac. 2005
• Indications et stratégies thérapeutiques des épistaxis dans la maladie de Rendu Osler. Babin E, Borsik M, Braccard S, Crampette L, Darrouzet V, Faure F, Fontanel JP, Houdart E, Jankowski R, Le Clech G, Malvezzi L, Morinière S, Perie S, Perret J, Pignat JC, Portier F, Serrano E, Plauchu H Rev Laryngol Otol Rhinol (Bord). 2005
• Frontolateral vertical partial laryngectomy without tracheotomy for invasive squamous cell carcinoma of the true vocal cord: a 25-year experience. Brumund KT, Gutierrez-Fonseca R, Garcia D, Babin E, Hans S, Laccourreye O. Ann Otol Rhinol Laryngol. 2005
• [Giant extradural epidermoid cyst of the posterior fossa]. Borha A, Emery E, Khouri S, Hitier M, Derlon JM. Neurochirurgie. 2005
• [Interest of PET/CT scan fusion to assess mandible involvement in oral cavity and oro pharyngeal carcinomas]. Babin E, Hamon M, Bénateau H, Desmonts C, Comoz F, Goullet de Rugy M, Béquignon A, Chesnay E. Ann Otolaryngol Chir Cervicofac. 2004
• How we do it: management of tracheobronchial foreign bodies in children. Babin E, Sigston E, Bigeon JY, Doppia MA, Edy E. Clin Otolaryngol Allied Sci. 2004
• Radiology quiz case 1. Childhood cavernous sinus thrombophlebitis. Babin E, Ndyaye M, Coskun O, Hamon M Arch Otolaryngol Head Neck Surg. 2004
• Risk of second primary cancer following differentiated thyroid cancer. Berthe E, Henry-Amar M, Michels JJ, Rame JP, Berthet P, Babin E, Icard P, Samama G, Galateau-Sallé F, Mahoudeau J, Bardet S. Eur J Nucl Med Mol Imaging. 2004
• Chirurgie de l'hyperthyroïdie : à propos de 43 patients. Viot A, Babin E, Bequignon A, Vadillo M, Valdazo A. Rev Laryngol Otol Rhinol (Bord).2003
• [Otogenic cavernous sinus thrombophlebitis. A case report]. Babin E, Ndyaye M, Bequignon A, Vadillo M, Moreau S, Valzado A, Jokic M, Coskun O, Hamon M. Ann Otolaryngol Chir Cervicofac. 2003
• Early response to chemotherapy in hypopharyngeal cancer: assessment with (11)C-methionine PET, correlation with morphologic response, and clinical outcome. Chesnay E, Babin E, Constans JM, Agostini D, Bequignon A, Regeasse A, Sobrio F, Moreau S. J Nucl Med. 2003
• Failure of antibiotic therapy in acute otitis media. Babin E, Lemarchand V, Moreau S, Goullet de Rugy M, Valdazo A, Bequignon A. J Laryngol Otol. 2003
• Anatomic variations of the arteries of the nasal fossa. Babin E, Moreau S, de Rugy MG, Delmas P, Valdazo A, Bequignon A. Otolaryngol Head Neck Surg. 2003
• Radiology quiz case 1. Epidural empyema after acute mastoiditis Babin E, Brenac F, Bequignon A, Edy E, Valdazo A, Moreau S. Arch Otolaryngol Head Neck Surg. 2003